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The resulting DHA-derived peroxidation adducts, such as 4-hydroxy-7-oxohept-5-enoic acid-lactone-glutathione (HOHA-lactone-GSH), 4,7-dihydroxyhept-5-enoic acid-lactone-glutathione (DHHA-lactone-GSH) and carboxyethylpyrrole (CEP), were quantified using LCMS/MS or immunohistochemistry

The dosing protocol for TB 500 generally starts with a loading phase

A future definitive trial would be based upon occurrence of adverse events (for example, inflammation and rejection) leading to implant removal in a maximum of 10% of cases, along with evidence of efficacy in the form of at least 60% of operated eyes having sustained decrease of keratometry at 6 months, sustained increase in central corneal thickness at 6 months, and minimum visual acuity improvement of one Snellen line of vision at 6 months

doi: 10.2337/DB14-0549 30 LandryLGAndersonAMRussHAYuLKentSCAtkinsonMAet al

3,417 adults with overweight or obesity but without type 2 diabetes